CLEANING IN PLACE (CIP) Module is the process used to ensure that, process reactors, vessels and lines are free of organic and inorganic contaminants:

Pharmaceuticals

Sterile Solutions
Vial
Ampoules
I. V. Fluids
Aerosols
LVP & SVP Solutions

Biopharmaceuticals

Vaccines
Human Insulin
Serums
Plasma Fractions
Bacteria & cell cultures

CIP cycles can be subjected to the following process machinery

Fermentors
Blending Vessels
Media / Harvest / Storage / Filtration Vessels
Transfer Lines
Process Equipment

Completely Automated Process Cycles
On line display of process parameters with P & I of Operating Systems
Display of Fault messages
Supervisory access code prevent unauthorized changes
Detergent / Acid / Alkali dosing
On Line pH, Conductivity, TOC Sensing
CIP is designed in accordance with ASME BPE and EHEDG guidelines
PLC-based, with Touch Screen MMI and SCADA Packages

Spray device characteristics

The cleaning liquid turns the spray head by means of a specially positioned nozzle
Rapid repitition impact loosens the dirt and washes it off the tank surface
The cleaning effects is optimum at low pressure in small to medium size tanks
With increasing pressure, the rotation speed gets higher, while due to stronger atomization, the reach of the spray gets lower
Operation at the optimum pressure ensures required cleaning results and avoids wear of the nozzle

Effective Cleaning Criteria Factors include

Cleaning Cycle Time
Cleaning Agent and Temperature
Concentration and Chemistry of the Cleaning Agent within the circuit
Degree of Turbulence of the Cleaning Solution
Characteristics of the surface being cleaned
Spray Device Selection (Static Dynamic)

Key Benefits

Validatable process for Sterilization of process equipment
Lower Facility Operating Costs
Minimal dismantling of equipment and piping
Reduced turnaround time for cleaning
WFI requirement for cleaning reduced significantly
Exposure to hazardous activities or entry into tanks, is eliminated